The Liang Group
Works after independent research

Works before independent research
33: Gaolin Liang, Hongjun Ren, and Jianghong Rao*. A biocompatible condensation reaction for controlled assembly of 
       nanostructures in living cells. Nat. chem.. 2010, 2: 54-60. (DOI: 10.1038/NCHEM.480)
32: Anca Dragulescu-Andrasi, Gaolin Liang, and Jianghong Rao. ¡°In vivo Bioluminescence Imaging of furin activity in
       breast  cancer cells using bioluminogenic substrates¡± Bioconjugate Chem.. 2009, 20: 1660-1666.
       ( DOI:10.1021/bc9002508)
31: Gaolin Liang, Zhimou Yang, Rongjun Zhang, Lihua Li, Yijun Fan, Yi Kuang, Yuang Gao, Ting Wang, W William Lu, and 
      Bing Xu. ¡°Supramolecular hydrogel of a D-aminoacid dipeptide for controlled drug release in vivo¡± Langmuir. 2009,  
      25(15): 8419-8422. (DOI: 10.1021/la804271d)
30: Cheng Yang, Gaolin Liang, Keming Xu, Ping Gao, and Bing Xu. ¡°Bactericidal functionalization of wrinkle-free fabrics
      via covalently bonding TiO2@Ag nanoconjugates¡± J. Mater. Sci.. 2009, 44(7): 1894-1901.
29: Jinhao Gao, Gaolin Liang, Jerry S Cheung, Yue Pan, Yi Kuang, Fan Zhao, Bei Zhang, Xixiang Zhang, Ed X Wu, and 
       Bing Xu. ¡°Multifunctional yolk-shell nanoparticles: A potential MRI contrast and anticancer agent¡± J. Am. Chem. Soc..
      2008, 130(35): 11828-11833. (DOI: 10.1021/ja803920b)
28: Kejun Cheng, Gaolin Liang, Changqi Hu. ¡°Acid-catalyzed epimerization of Kobophenol A to Carasinol B¡± Molecules
      2008, 13(4): 938-942.
27: Keming Xu, Weiwei Ge, Gaolin Liang, Ling Wang, Zhimou Yang, Qigang Wang, I-Ming Hsing, and Bing Xu*
      "Bisphosphonate-containing supramolecular hydrogels for topical decorporation of uranium-contaminated wounds in
      mice" Int. J. Radiat. Biol.. 2008, 84(5): 353-362.
26: Zhimou Yang, Gaolin Liang, and Bing Xu* "Enzymatic hydrogelation of small molecules" Acc. Chem.
      Res.. 2008, 41(2): 315-326. (DOI: 10.1021/ar7001914)
25: Gaolin Liang, Keming Xu, Lihua Li, Liang Wang, Yi KuangY, Zhimou Yang, and Bing Xu* "Using Congo red to report
      intracellular hydrogelation resulted from self-assembly of small molecules" Chem. Commun.. 2007,
      4096-4098. (DOI: 10.1039/B712971H)
24: Zhimou Yang, Gaolin Liang, Zufeng Guo, Zhihong Guo, and Bing Xu* "Intracellular Hydrogelation of Small Molecules
      Inhibits Bacterial Growth" Angew. Chem. Int. Ed.. 2007, 46(43) 8216-8219.
23: Zhimou Yang, Gaolin Liang, Manlung Ma, Yuan Gao, and Bing Xu* "In Vitro and In Vivo Enzymatic Formations of
      Supramolecular Hydrogels Based on Self-Assembled Nanofibers of a beta-Amino Acid Derivative" Small. 2007, 3(4):
      558-562. (DOI: 10.1002/small.200700015)
22: Zhimou Yang, Gaolin Liang, and Bing Xu* "Enzymatic Control of the Self-Assembly of Small Molecules: A New Way to
      Generate Supramolecular Hydrogels" Soft Matter. 2007, 3: 515-520. (Highlight) (DOI: 10.1039/B700138J)
21: Zhimou Yang, P. L. Ho, Gaolin Liang, K. H. Chow, Qigang Wang, Yang Cao, Zhihong Guo, and Bing Xu* "Using
      beta-Lactamase to Trigger Supramolecular Hydrogelation" J. Am. Chem. Soc.. 2007,
     129(2): 266-267. (DOI: 10.1021/ja0675604)
20: Jinhao Gao, Gaolin Liang, Bei Zhang, Yi Kuang, Xixiang Zhang, and Bing Xu* "FePt@CoS2 Yolk-shell Nanocrystals
      as A Potent Agent to Kill HeLa Cells" J. Am. Chem. Soc.. 2007, 129(5): 1428-1433.
     (DOI: 10.1021/ja067785e)
19: Zhimou Yang, Gaolin Liang, Manlung Ma, A. Sunny Abbah,  William Lu, and Bing Xu* "D-glucosamine-based
      supramolecular hydrogels to improve wound healing" Chem. Commun.. 2007, 843-845.
     (DOI: 10.1039/B616563J)
18: Zhimou Yang, Gaolin Liang, Manlung Ma, Yuan Gao, and Bing Xu* "Conjugates of naphthalene and dipeptides confer
      molecular hydrogelators with high efficiency of hydrogelation and superhelical nanofibers" J. Mater.
      Chem.. 2007, 17, 850-854. (DOI: 10.1039/B611255B)
16: Gaolin Liang, Ling Wang, Zhimou Yang, Hokee Koon, Naiki Mak, Chi K Chang*, and Bing Xu* "Using enzymatic
      reaction to enhance photodynamic therapy effect of porphyrin dityrosine phosphates" Chem. Commun..
      2006, 5021-5023. (DOI: 10.1039/B611557H)
15:  Zhimou Yang, Gaolin Liang, Ling Wang, and Bing Xu. Using a Kinase / hosphatase Switch to Regulate a
       Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in Vivo. J. Am. Chem.
       Soc.. 2006, 128(9): 3038-3043. (DOI: 10.1021/ja057412y)
14: Zhimou Yang, Gaolin Liang, and Bing Xu. Supramolecular hydrogels based on ¦Â-amino acid derivatives. Chem.
      Commun.. 2006, 738-740. (DOI: 10.1039/B516133A)
13: Gaolin Liang, Jingbo Bi, Qinghong Huang, Su Zhang, Changqi Hu. Metabolites and the pharmacokinetics of
      kobophenol A from Caragana sinica in rats. Journal of Ethnopharmacology. 2005, 101 (3): 324-329.
12: Gaolin Liang, Tong Zhang, Jingmei Wang, Buyun Chen, Kejun Cheng, and Changqi Hu. X-ray single crystal analysis of
      (-)-(S)-equol from rats¡¯ feces fed the phytoestrogen daidzin. Chemistry & Biodiversity. 2005, 2 (7): 959-963.
11: Gaolin Liang, Lisheng Qian, Yiling Cui, and Changqi Hu. Formation of oxidative metabolite from kobophenol A by
      human intestinal bacterium Klebsilla pneumoniae. Chemistry & Biodiversity. 2005, 2 (4): 506-509.
10: Fusheng Zhou, Weidong Tang, Qin Mu, Guoxun Yang, Yang Wang, Gaolin Liang, Liguang Lou. Semisynthesis and
       antitumor activities of new styryl-lactone derivatives. Chemical and Pharmaceutical Bulletin. 2005, 53(11):
9: Buyun Chen, Gaolin Liang, Qichun Mei. Isolation and identification of two effective compositions from the roots of
    Cargana sinica and study on its physiological activities . Fudan University Journal of Medical Sciences. 2005, 32 (6):
8: Gaolin Liang, Kejun Cheng, Hong Zhou and Changqi Hu. Koboquinone A and B, New Metabolites of Kobophenol A in
    Rats. Chemical and Pharmaceutical Bulletin. 2004, 52(12): 1489-1491.
7: Gaolin Liang, Yanhua Yu and Zhiming Chen. Synthesis of 3,3,10,10- Teramethyl -4,9-Diazadodecan-2,11-Dione
    Dioxime. Chinese Journal of Pharmaceuticals. 2003, 34(10):492-493
6: Gaolin Liang, Yanhua Yu, Zhiming Chen, et al. Synthesis of Methylenediphosphonic Acid. Chinese Journal of Modern
    Applied Pharmaceuticals. 2002, 19(3): 212-213
5: Gaolin Liang, Mingyang Hu, Yanhua Yu. Synthesis of Etifenin. Chinese Journal of Modern Applied Pharmaceuticals.
      2001, 18(2): 117-118
4: Gaolin Liang, Mingyang Hu, Bocheng Wang. Synthesis of Disodium 3-Amino-1- Hydroxy- Propilidene- 1,1-
     Diphosphonate. Chinese Journal of Modern Applied Pharmaceuticals. 1999, 16(2): 37-38
3: Rongjun Zhang, Jian Jin, Gaolin Liang, Weixing Wan, et al. Preparation and preclinical studies of a hepatic receptor
     imaging agent. Nuclear Science and Techniques. 1998, 9(3):189-192
2: Gaolin Liang, Jian Jin, Mingyang Hu, et al. Synthesis of Sialoglycoprotein. Chinese Journal of Pharmaceuticals.
    1998, 29(6): 248-249
1: Gaolin Liang, Mingyang Hu, Jian Jin. Synthesis of Cyanomethyl 1-Thioglycoside, Precusor of Liver galactose  Receptor
    Imaging Agent. Chinese Journal of Pharmaceuticals. 1997, 28(1): 37-38

56: Yue Yuan, Xijun Wang, Bin Mei, Dongxin Zhang, Anming Tang, Linna An, Xiaoxiao He, Jun Jiang*, and Gaolin Liang*. Labeling Thiols on Proteins, Living Cells, and Tissues with Enhanced Emission Induced by FRET. Sci. Rep., 2013. 3, 3523 (DOI: 10.1038/srep03523).
55: Fuqiang Wang, Ling Wang, Zhonghua Shi, and Gaolin Liang*. Comparative N-glycoproteomic and Phosphoproteomic Profiling of Human Placental Plasma Membrane between Normal and Preeclampsia Pregnancies with High-Resolution Mass Spectrometry. PLOS One. 2013, 8(11): e80480. (DOI: 10.1371/ journal.pone.0080480).
54: Fuqiang Wang, Zhonghua Shi, Ping Wang, Wei You, and Gaolin Liang*. Comparative proteome profile of human placenta from normal and preeclamptic pregnancies. PLOS One. 2013, 8(10): e78025. (DOI:10.1371/journal.pone.0078025).
53: Anming Tang, Bin Mei, Weijuan Wang, Wanglai Hu, Fang Li, Jun Zhou, Qing Yang, Hua Cui, Mian Wu, and Gaolin Liang*.FITC-quencher based, caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells. Nanoscale. 2013, 5 (19), 8963-8967. (DOI: 10.1039/C3NR03339B ).
52: Rui Huang,# Xijun Wang,# Dingli Wang, Fang Liu, Bin Mei, Anming Tang, Jun Jiang*, and Gaolin Liang*Multifunctional Fluorescent Probe for SequentialDetections of Glutathione and Caspase-3 in Vitro and in Cells. Anal. Chem.. 2013, 85, 6203-6207. DOI: 10.1021/ac4014012. #: Co-first author.
51:Yun Deng, Yufeng Luo, Linna An, M. Rehan H. Shah Gilani, and Gaolin Liang*. Covalently Conjugating Fluorescence Probes to Nanoparticles for Signal Enhancement. Chem. Lett.. 2013, 42 (10), 1157-1159. (DOI: 10.1246/cl.130424).
50: Anming Tang,# Weijuan Wang,# Bin Mei, Wanglai Hu, Mian Wu, and Gaolin Liang*. DEVD-Based Hydrogelator Minimizes Cellular Apoptosis Induction. Sci. Rep.. 2013, 3: 1848. (DOI: 10.1038/srep01848). #: Co-first author.
49: Fuqiang Wang, Ling Wang, Zhiyang Xu, and Gaolin Liang*. Identification and Analysis of Multi-protein Complexes in Placenta. PLOS One. 2013, 8 (4): e62988. (DOI:10.1371/journal.pone.0062988)
48: Longfei Liu, Qingqing Miao, and Gaolin Liang*. Quantim Dots as Multifunctional Materials for Tumor Imaging and Therapy. Materials. 2013, 6, 483-499. (DOI: 10.3390/ma6020483)
47: Yue Yuan, Jia Zhang, Mengjing Wang, Bin Mei, Yafeng Guan, and Gaolin Liang*. Detection of Glutathione in Vitro and in Cells by the Controlled Self-assembly of Nanorings. Anal. Chem.. 2013, 85, 1280-1284. (DOI: 10.1021/ac303183v)
46: Chunyan Cao, Huijing Liu, and Gaolin Liang*. Direct imaging furin-controlled intracellular condensation with two-photon laser microscope. Protocol Exchange. 2013, (DOI: 10.1038/protex.2013.005).

45: Chunyan Cao, Yingying Shen, Jiandong Wang,  Li Li*, and Gaolin Liang*. Controlled intracellular self-assembly of   gadolinium nanoparticles as smart molecular MR contrast agents. Sci. Rep.. 2013, 3, 1024. (DOI:  10.1038/srep01024).

44: Mengjing Wang, Yue Yuan, and Gaolin Liang*. "Click Chemistry" for Molecular Imaging. Curr. Mol. Imaging. 2012, 1, 87-95. (DOI: 10.2174/2211212700123115552).

43: Xingyi Li, Chengbiao Yang, Zhaoliang Zhang, Zhidan Wu, Yun Deng, Gaolin Liang, Zhimou Yang, and Hao Chen*. Folic acid as a versatile motif to construct molecular hydrogelators through conjugations with hydrophobic therapeutic agents. J. Mater. Chem.. 2012, 22 (41), 21838-21840. (DOI: 10.1039/C2JM35329F)

42:  Qingqing Miao, Xiaoyu Bai, Yingying Shen, Bin Mei, Jinhao Gao, Li Li, and Gaolin Liang*. Intracellular self-assembly of nanoparticles for enhancing cell uptake. Chem. Commun.. 2012, 48 (78), 9738-9740.    (DOI: 10.1039/C2CC34899C).

41:  Xiaojing Wang, Qian Li, Yue Yuan, Bin Mei, Rui Huang, Ying Tian, Jing Sun, Chunyan Cao, Guangming Lu, and Gaolin Liang*. New method for effectively and quantitatively labeling cysteine residues on chicken eggshell membrane. Org. Biomol. Chem. 2012, 10, 8082-8086. (DOI: 10.1039/C2OB26279G).

40:  Yue Yuan, Jia Zhang, Gaolin Liang*, Xiurong Yang*.  Rapid fluorescent detection of neurogenin3 by CdTe quantum dotaggregation. Analyst. 2012, 137, 1775-1778. (DOI: 10.1039/C2AN16166D)

39: Xiaoli Zhang, Xinlei Chu, Ling Wang, Huaimin Wang, Gaolin Liang, Jinxiu Zhang, Jiafu Long*, and Zhimou Yang*.   Rational Design of A Tetrameric Protein to Enhance Interactions Between Self-assembled Fibers Confers Molecular Hydrogels. Angew. Chem. Int. Ed.. 2012, 51, 4388-4392. (DOI: 10.1002/anie. 201108612)

38: Yue Chen, and Gaolin Liang*. Enzymatic self-assembly of nanostructures for theranostics. Theranostics. 2012; 2(2):  139-147. (DOI: 10.7150/thno.3696).

37:  Yun Deng, Shuang Liu, Kun Mei, Anming Tang, Chunyan Cao, and Gaolin Liang*. Multifunctional small molecule for  controlled assembly of oligomeric nanoparticles and crosslinked polymers. Org. Biomol. Chem..   2011, 9, 6917-6919. (DOI: 10.1039/C1OB06132A)

36:  Chunyan Cao, Yue Chen, Fangzhou Wu, Yun Deng, and Gaolin Liang*. Caspase-3 controlled assembly of       nanoparticles for fluorescence turn on. Chem. Commun.. 2011, 47, 10320-10322. (DOI: 10.1039/C1CC14112K)

35:  Gaolin Liang, John Ronald, Yuanxin Chen, Deju Ye, Prachi Pandit, Manlung Ma,  Brian Rutt, and Jianghong Rao.    Controlled Self-Assembling of Gadolinium Nanoparticles as "Smart" Molecular Magnetic Resonance Imaging Contrast     Agents. Angew. Chem. Int. Ed.. 2011, 50: 6283-6285. (DOI: 10.1002/anie.201007018)

34: Deju Ye, Gaolin Liang, Manlung Ma, and Jianghong Rao. Controlling intracellular macrocyclization for the imaging of protease activity. Angew. Chem. Int. Ed.. 2011, 50: 2275-2279. (DOI: 10.1002/anie.201006140)

63: Weijuan Wang,# Junchao Qian,# Anming Tang,# Linna An, Kai Zhong,* Gaolin Liang*. Using Magnetic Resonance Imaging to Study Enzymatic Hydrogelation. Anal. Chem.. 2014, 86, 5955-5961. (DOI: 10.1021/ac500967x). #: Co-first author.
62: Yue Yuan, Jia Zhang, Linna An, Qinjingwen Cao , Yun Deng, Gaolin Liang*. Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging. Biomaterials. 2014, 35, 7881-7886. (DOI: 10.1016/j.biomaterials.2014.05.071).
61: Shiyuan Li, Duyu Chen, Qingtong Zhou, Wei Wang, Lingfeng Gao, Jie Jiang, Haojun Liang, Yangzhong Liu, Gaolin Liang, Hua Cui*. A general chemiluminescence strategy for measuring aptamer-target binding and target concentration. Anal. Chem.. 2014, 86, 5559-5566. (DOI: 10.1021/ac501061c).
60: Xiaojing Wang, Qingqing Miao, Tingjie Song, Qingpan Yuan, Jinhao Gao, and Gaolin Liang*. Fluorescence switch for sequentially and selectively sensing copper (II) and L-histidine in vitro and in living cells. Analyst. 2014, 139, 3360-3364 (DOI: 10.1039/C4AN00410H).
59: Yue Yuan, Shenlong Jiang, Qingqing Miao, Jia Zhang, Mengjing Wang, Linna An, Qinjingwen Cao, Yafeng Guan, Qun Zhang*, and Gaolin Liang*. Fluorescent switch for fast and selective detection of mercury (II) ions in vitro and in living cells and a simple device for its removal. Talanta. 2014, 125, 204-209 (DOI: 10.1016/j.talanta.2014.02.063).
58: Linna An, M.Rehan H Shah Gilani, and Gaolin Liang*. Peptide-based Nanostructures for Cancer Diagnosis and Therapy. Curr. Med. Chem.. 2014, 21, 2453-2466.
57: Yue Yuan and Gaolin Liang*. A biocompatible, highly efficient click reaction and its applications. Org. Biomol. Chem., 2014, 12(6), 865-871 (DOI: 10.1039/C3OB41241E). (accepted)
2015 (Total IF: 114.196; Average IF: 8.157)
77: Wei Du, Yue Yuan, Lin Wang, Yusi Cui, Hui Wang, Huiqin Xu*, and Gaolin Liang*. Multifunctional Bioconjugate for Cancer Cell-Targeted Theranostics. Bioconjugate Chem., 2015,  26 (12), 2571-78. (DOI: 10.1021/acs.bioconjchem.5b00570).
76: Bin Mei,# Qingqing Miao,# Anming Tang, and Gaolin Liang*. Enzyme-instructed self-assembly of taxol promotes axonal branching. Nanoscale. 2015, 7, 15605-15608 (DOI: 10.1039/C5NR04563K). #: Co-first author.
75: Yue Yuan, Di Li, Jia Zhang, Xianmin Chen, Chi Zhang, Zhanling Ding, Lin Wang, Xueqian Zhang, Junhua Yuan, Yinmei Li, Yanbiao Kang, and Gaolin Liang*. Bridging cells of three colors with two bio-orthogonal click reactions. Chem. Sci.. 2015, 6, 6425-6431 (DOI: 10.1039/C5SC01315A).

74: Ling Dong, Qingqing Miao, Zijuan Hai, Yue Yuan, and Gaolin Liang*. Enzymatic Hydrogelation-Induced Fluorescence Turn-Off for Sensing Alkaline Phosphatase in Vitro and in Living Cells. Anal. Chem.. 2015, 87(13), 6475-6478 (DOI: 10.1021/acs.analchem.5b01657).
73: Yaling Liu,# Qingqing Miao,# Pei Zou, Longfei Liu, Xiaojing Wang, Linna An, Xiaoliu Zhang, Xiangping Qian, Shineng Luo,* and Gaolin Liang*. Enzyme-Controlled Intracellular Self-Assembly of 18F Nanoparticles for Enhanced MicroPET Imaging of Tumor. Theranostics. 2015, 5(10), 1058-1067 (DOI: 10.7150/thno.11758). #: Co-first author.
72: Qingqing Miao, Chunying Yin, Maolin Xie, Yufeng Luo, Zijuan Hai, Qingpan Yuan, Jun Jiang, and Gaolin Liang*. Gathering nanorings via Fe2+-bipyridine coordination. Chem. Commun.. 2015, 51, 11045-11047 (DOI: 10.1039/C5CC02694F).
71: Yue Yuan,# Lin Wang,# Wei Du, Zhanling Ding, Jia Zhang, Tao Han, Linna An, Huafeng Zhang*, and Gaolin Liang*. Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multi-Drug Resistance. Angew. Chem. Int. Ed.. 2015, 54, 9700-9704 (DOI: 10.1002/anie.201504329 and 10.1002/ange.201504329). #: Co-first author.
70: Yue Yuan, Jia Zhang, Qinjingwen Cao, Linna An, Gaolin Liang*. Intracellular Disassembly of Self-Quenched Nanoparticles Turns NIR Fluorescence on for Sensing Furin Activity in Cells and in Tumors. Anal. Chem.. 2015, 87(12), 6180-6185 (DOI: 10.1021/acs.analchem.5b01656).
69: Yue Yuan, Shuchao Ge, Hongbin Sun, Xuejiao Dong, Hongxin Zhao, Linna An, Jia Zhang, Junfeng Wang, Bing Hu, Gaolin Liang*. Intracellular Self-Assembly and Disassembly of 19F Nanoparticles Confer Respective “Off” and “On” 19F NMR/MRI Signals for Legumain Activity Detection in Zebrafish. ACS Nano. 2015, 9(5), 5117-5124 (DOI: 10.1021/acsnano.5b00287).
68: Qingqing Miao, Qing Li, Qingpan Yuan, Lingli Li, Zijuan Hai, Shuang Liu, and Gaolin Liang*. Discriminative Fluorescence Sensing of Biothiols in Vitro and in Living Cells. Anal. Chem.. 2015, 87 (6), 3460-3466 (DOI: 10. 1021/ac504836a).
67: Zijuan Hai, Yajie Bao, Qingqing Miao, Xiaoyi Yi, and Gaolin Liang*. Pyridine-Biquinoline-Metal Complexes for Sensing Pyrophosphate and Hydrogen Sulfide in Aqueous Buffer and in Cells. Anal. Chem.. 2015, 87 (5), 2678-2684 (DOI: 10.1021/ac504536q).

66: Shuang Liu, Anming Tang, Maolin Xie, Yundan Zhao, Jun Jiang, and Gaolin Liang*. Oligomeric Hydrogels Self-Assembled from Reduction-Controlled Condensation. Angew. Chem. Int. Ed.. 2015, 54 (12), 3639-3642 (DOI: 10.1002/anie.201409952).
65: Qingqing Miao, Ziye Wu, Zijuan Hai, Changlu Tao, Qingpan Yuan, Yadi Gong, Yafeng Guan, Jun Jiang,* and Gaolin Liang*. Bipyridine hydrogel for selective and visible detection and absorption of Cd2+. Nanoscale. 2015, 7, 2797 - 2804
64: Yue Yuan,# Hongbin Sun,# Shuchao Ge,# Mengjing Wang, Hongxin Zhao, Lin Wang, Linna An, Jia Zhang, Huafeng Zhang, Bing Hu*, Junfeng Wang*, Gaolin Liang*. Controlled Intracellular Self-assembly and Disassembly of 19F Nanoparticles for MR Imaging of Caspase 3/7 in Zebrafish. ACS Nano. 2015, 9 (1), 761-768 (DOI: 10.1021/nn5062657). #: Co-first author.

2016 (Total IF: 103.616; Average IF: 8.635)
92: Zhen Zheng,# Anming Tang,# Yong Guan, Liang Chen, Fuqiang Wang, Peiyao Chen, Weijuan Wang, Yufeng Luo, Yangchao Tian and Gaolin Liang*.  Nanocomputed Tomography Imaging of Bacterial Alkaline Phosphatase Activity with an Iodinated Hydrogelator. Anal. Chem. 2016, 88(24), 11982-85 (DOI: 10.1021/ acs.analchem.6b04139). #, co-first author.
91: Bin Mei and Gaolin Liang*Paclitaxel Hydrogelator Delays Microtubule Aggregation. Chin. J. Chem. Phys.  2017, 30(2), 239-242.
90: Zhen Zheng and Gaolin Liang*Magnetic resonance imaging-guided stratified selection of patients for nano-therapy. Ann. Transl. Med. 2016, 4(Suppl 1), S54 (DOI: 10.21037/atm.2016.10.07).
89: Zhen Zheng, Peiyao Chen, Maolin Xie, Chengfan Wu, Yufeng Luo, Wentao Wang, Jun Jiang and Gaolin Liang*Cell Environment-Differentiated Self-Assembly of Nanofibers. J. Am. Chem. Soc. 2016, 138(35), 11128-11131 (DOI: 10.1021/jacs.6b06903).
88: Zhen Zheng,# Peiyao Chen,# Gongyu Li,# Yunxia Zhu,# Zhonghua Shi, Yufeng Luo, Chun Zhao, Ziyi Fu,  Xianwei Cui, Chenbo Ji, Fuqiang Wang,* Guangming Huang,* and Gaolin Liang*Mechanistic study of CBT-Cys click reaction and its application for identifying bioactive N-terminal cysteine peptides in amniotic fluid. Chem. Sci. 2017, 8, 214-222 (DOI: 10.1039/C6SC01461E). #, co-first author.
87: Zhen Zheng,# Jihao Wang,# Peiyao Chen, Maolin Xie, Lei Zhang, Yubin Hou, Xin Zhang, Jun Jiang, Junfeng Wang,* Qingyou Lu,* and Gaolin Liang*Using L-STM to directly visualize enzymatic self-assembly/disassembly of nanofibers. Nanoscale 2016, 8, 15142-15146 (DOI: 10.1039/C6NR03056D). #, co-first author.
86: Yue Yuan,# Fuqiang Wang,# Wei Tang, Zhanling Ding, Lin Wang, Lili Liang, Zhen Zheng, Huafeng Zhang, and Gaolin Liang*Intracellular Self-Assembly of Cyclic D-Luciferin Nanoparticles for Persistent Bioluminescence Imaging of Fatty Acid Amide Hydrolase. ACS Nano 2016, 10(7), 7147-7153 (DOI: 10.1021/acsnano.6b03412). #, co-first author.
85: Fenfen Li, Debo Zhi, Yufeng Luo, Jiqian Zhang, Xiang Nan, Yunjiao Zhang, Wei Zhou, Bensheng Qiu,* Longping Wen,* and Gaolin Liang*. Core/shell Fe3O4/Gd2O3 nanocubes as T1-T2 dual modal MRI contrast agents. Nanoscale 2016, 8, 12826-12833 (DOI: 10.1039/C6NR02620F).
84: Anming Tang,# Yu Qian,# Shuang Liu,# Weijuan Wang, Bing Xu, An Qin,* and Gaolin Liang*. Self-assembling bisphosphonates into nanofibers to enhance their inhibitory capacity on bone resorption. Nanoscale 2016, 8, 10570-10575 (DOI: 10.1039/C6NR00843G). #, co-first author.
83: Zhen Zheng, Lin Wang,  Wei Tang, Peiyao Chen, Hui Zhu, Yue Yuan, Gongyu Li, Huafeng Zhang, and Gaolin Liang*. Hydrazide D-luciferin for in vitro selective detection and intratumoral imaging of Cu2+. Biosens. Bioelectron. 2016, 83, 200-204 (DOI: 10.1016/j.bios.2016.04.067).
82: Yue Yuan,# Zhanling Ding,# Junchao Qian, Jia Zhang, Jinyong Xu, Xuejiao Dong, Tao Han, Shuchao Ge, Yufeng Luo, Yuwei Wang, Kai Zhong,* and Gaolin Liang*. Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis. Nano Lett. 2016, 16 (4), 2686-2691 (DOI: 10.1021/acs.nanolett.6b00331). #, co-first author
81: Xiaomei Liu, Shuang Liu, and Gaolin Liang*. Fluorescence turn-on for highly selective detection of nitric oxide in vitro and in living cells. Analyst 2016,141, 2600-2605 (DOI: 10.1039/C6AN00110F).
80: Zhen Zheng, Hongbin Sun, Chen Hu, Gongyu Li, Xiaomei Liu, Peiyao Chen, Yusi Cui, Jing Liu, Junfeng Wang, and Gaolin Liang*. Using “On/Off” 19F NMR/MRI Signals to Sense Tyrosine Kinase/Phosphatase Activity in Vitro and in Cell Lysates. Anal. Chem. 2016, 88(6), 3363-3368 (DOI: 10.1021/acs.analchem.6b00036).
79: Yusi Cui, Wei Du, and Gaolin Liang*. Self-Assembly/Disassembly of Nanostructures Confers “Off/On” Signal for Molecular Imaging. ChemNanoMat 2016, 2(5) 344-353 (DOI: 10.1002/cnma.201600052).
78: Shuang Liu, Yufeng Luo, and Gaolin Liang*. In situ clicking methylglyoxal for hierarchical self-assembly of nanotubes in supramolecular hydrogel. Nanoscale. 2016, 8, 766-769. (DOI: 10.1039/C5NR07179H).
2017 (Total IF: 85.871; Average IF: 7.806)
103: Wei Tang, Jingbo Yang, Zhibin Zhao, Zhexiong Lian and Gaolin Liang*. Intracellular coassembly boosts the anti-inflammation capacity of dexamethasone. Nanoscale, 2017, 9, 17717-17721 (DOI:10.1039/C7NR07197C).
102: Jinhui Jiang, Zhibin Zhao, Zijuan Hai, Hongyong Wang, and Gaolin Liang*. Intracellular Proteolytic Disassembly of Self-Quenched NIR Nanoparticles Turns Fluorescence on for Tumor-Targeted Imaging. Anal. Chem. 2017, 89(18), 9625-9628 (DOI: 10.1021/ acs.analchem.7b02971).
101: Chengfan Wu,# Zhen Zheng,# Yuenan Guo, Chongli Tian, Qiang Xue,* and Gaolin Liang*.  Fluorine substitution enhances the self-assembling ability of hydrogelators. Nanoscale  2017, 9, 11429-11433 (DOI: 10.1039/C7NR02499A). #, equal contribution.
100: Ling Dong, Junchao Qian, Zijuan Hai, Jinyong Xu, Wei Du, Kai Zhong,* and Gaolin Liang*. Alkaline Phosphatase-Instructed Self-Assembly of Gadolinium Nanofibers for Enhanced T2-Weighted Magnetic Resonance Imaging of Tumor. Anal. Chem. 2017, 89(13), 6922-6925 (DOI: 10.1021/ acs.analchem.7b00621).
99: Zijuan Hai, Jingjing Wu, Lin Wang, Jiacheng Xu, Huafeng Zhang, and Gaolin Liang*. Bioluminescence Sensing of γ-Glutamyltranspeptidase Activity in Vitro and in Vivo. Anal. Chem. 2017, 89(13), 7017-7021 (DOI: 10.1021/ acs.analchem.7b00567).
98: Peiyao Chen, Zhen Zheng, Yunxia Zhu, Yu Dong, Fuqiang Wang,* and Gaolin Liang*. Bioluminescent Turn-On Probe for Sensing Hypochlorite in Vitro and in Tumors. Anal. Chem. 2017, 89(11), 5693-5696 (DOI: 10.1021/ acs.analchem.7b01103).
97: Wei Tang,# Jingbo Yang,# Yue Yuan,  Zhibin Zhao, Zhexiong Lian* and Gaolin Liang*.  Paclitaxel nanoparticle awakens immune system to fight against cancer. Nanoscale  2017, 9, 6529-6536 (DOI: 10.1039/C6NR09895A
). #, equal contribution
96: Zhen Zheng, Gongyu Li, Chengfan Wu, Miaomiao Zhang, Yue Zhao, and Gaolin Liang*.  Intracellular synthesis of D-aminoluciferin for bioluminescence generation. Chem. Commun.  2017, 53, 3567-3570 (DOI: 10.1039/C7CC00999B).
95: Ning Zhou, Xiaoyan Cao, Xuewen Du, Huaimin Wang, Ming Wang, Shuang Liu, Khang Nguyen, Klaus Schmidt-Rohr, Qiaobing Xu, Gaolin Liang and Bing Xu*Hyper-Crosslinkers Lead to Temperature- and pH-Responsive Polymeric Nanogels with Unusual Volume Change. Angew. Chem. Int. Ed.. 2017, 56(10), 2623-2627 (DOI: 10.1002/anie.201611479).
94: Zijuan Hai, Jindan Li, Jingjing Wu, Jiacheng Xu and Gaolin Liang*Alkaline Phosphatase-Triggered Simultaneous Hydrogelation and Chemiluminescence. J. Am. Chem. Soc.  2017. 139(3), 1041-1044 (DOI: 10.1021/jacs.6b11041). (Open Access).
93: Xiaomei Liu and Gaolin Liang*Dual aggregation-induced emission for enhanced fluorescence sensing of furin activity in vitro and in living cells. Chem. Commun.  2017, 53, 1037-40 (DOI: 10.1039/C6CC09106G). (Back Cover).
117, Chengfan Wu, Rui Zhang, Wei Du, Liang Cheng,* and Gaolin Liang*. Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for the Enhanced Photoacoustic Imaging of Tumors. Nano Lett. 2018, 18(12), 7749-7754(DOI: 10.1021/acs.nanolett.8b03482).
116, Wei Tang, Zhibin Zhao, Yuanyuan Chong, Chengfan Wu, Qingzhi Liu, Jingbo Yang, Rongbin Zhou, Zhe-Xiong Lian,* and Gaolin Liang*. Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect. ACS Nano 2018, 12(10), 9966-9973(DOI: 10.1021/acsnano.8b04143). 
115, Jindao Wu,* Zhen Zheng, Yuanyuan Chong, Xiangcheng Li, Liyong Pu, Qiyun Tang, Liu Yang, Xuehao Wang,* Fuqiang Wang,*, and Gaolin Liang*. Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection. Adv. Mater. 2018, 30(45), 1805018 (DOI: 10.1002/adma.201805018).Video Abstract:
114, Yue Zhao, Zijuan Hai, Hongyong Wang, Lanhong Su, and Gaolin Liang*. Legumain-Specific Near-Infrared Fluorescence “Turn On” for Tumor-Targeted Imaging. Anal. Chem. 2018,  90(15), 8732-8735 (DOI: 10.1021/acs.analchem.8b02704).
113, Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng*, Wei Jiang*, and Rongbin Zhou*. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat. Commun. 2018, 9, 2550 (DOI: 10.1038/s41467-018-04947-6).
112, Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang,* and Rongbin Zhou*. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol. Med. 2018, 10: e8689 (DOI: 10.15252/emmm.201708689).
111, Miaomiao Zhang and Gaolin Liang*. Applications of CBT-Cys click reaction: past, present, and future. Sci. China Chem. 2018, 61(9), 1088-1098 (DOI: 10.1007/s11426-018-9277-6).
110, Zijuan Hai and Gaolin Liang*. Intracellular Self-Assembly of Nanoprobes for Molecular Imaging. Adv. Biosys. 2018, 2(8), 1800108 (DOI: 10.1002/adbi.201800108).
109, Miaomiao Zhang, Lin Wang, Yangyang Zhao, Fuqiang Wang, Jindao Wu*, and Gaolin Liang*. Using Bioluminescence Turn-On to Detect Cysteine in Vitro and in Vivo. Anal. Chem. 2018, 90(8), 4951-4954 (DOI: 10.1021/acs.analchem.8b00682).
108, Jindan Li, Zijuan Hai, Huiqiong Xiao, Xiaoyi Yi*, and Gaolin Liang*. Intracellular self-assembly of Ru(bpy)32+ nanoparticles enables persistent phosphorescence imaging of tumor. Chem. Commun. 2018, 54, 3460-3463 (DOI: 10.1039/C8CC01759J)
107, Sonia Kiran, Zijuan Hai, Zhanling Ding, Lin Wang, Yaling Liu, Huafeng Zhang, and Gaolin Liang*. Alkaline phosphatase-triggered assembly of etoposide enhances its anticancer effect. Chem. Commun. 2018, 54, 1853-1856 (DOI: 10.1039/C7CC09365A).

106, Zijuan Hai, Jingjing Wu, Dilizhatai Saimi, Yanhan Ni, Rongbin Zhou, and Gaolin Liang*. Smart Dual Quenching Strategy Enhances the Detection Sensitivity of Intracellular Furin. Anal. Chem. 2018, 90(3), 1520-1524 (DOI: 10.1021/ acs.analchem.7b05251).
105, Wei Du, Xiaomu Hu, Weichen Wei, and Gaolin Liang*. Intracellular Peptide Self-Assembly: A Biomimetic Approach for in Situ Nano-drug Preparation. Bioconjugate Chem. 2018, 29(4), 826-837 (DOI: 10.1021/ acs.bioconjchem.7b00798).
104: Wei Tang,# Zhibin Zhao,# Zhexiong Lian, and Gaolin Liang*. Fluorogenic Disassembly of Self-Quenched NIR Nanoparticles Enables Matrix Metalloproteinase Detection. J. Biomed. Nanotechnol. 2018, 14, 304-311 (DOI: 10.1166/ jbn.2017.2473). #, equal contribution.
2018 (Total IF: 115.092; Average IF: 8.853)
125, Yanhan Ni, Zijuan Hai, Tong Zhang, Yanfang Wang, Yanyun Yang, Shusheng Zhang*, and Gaolin Liang*. Cathepsin B Turning Bioluminescence “On” for Tumor Imaging. Anal. Chem. 2019, 91, 23, 14834–14837 (DOI: 10.1021/acs.analchem.9b04254).
124, Hongyong Wang, Peiyao Chen, Hao Wu, Pei Zou, Jun Wu, Yaling Liu*, and Gaolin Liang*. Furin-Guided Intracellular 68Ga Nanoparticle Formation Enhancing Tumor MicroPET Imaging. Anal. Chem. 2019, 91, 23, 14842–14845 (DOI: 10.1021/acs.analchem.9b04788).
123, Wei Du, Yuanyuan Chong, Xiaomu Hu, Yanfang Wang, Yu Zhu, Jihua Chen, Xiaoxia Li, Qun Zhang, Guangfeng Wang,* Jun Jiang,* and Gaolin Liang*. Increasing Photothermal Efficacy by Simultaneous Intra- and Intermolecular Fluorescence Quenching. Adv. Funct. Mater. 2020, 30, 1908073 (DOI: 10.1002/adfm.201908073).
122, Peiyao Chen, Wen Kuang, Zhen Zheng, Shuye Yang, Yaling Liu, Lanhong Su, Kui Zhao,* and Gaolin Liang*.Carboxylesterase-Cleavable Biotinylated Nanoparticle for Tumor-Dual Targeted Imaging.Theranostics 20199(24), 7359-7369 (DOI: 10.7150/thno.37625). 

121, Zhanling Ding, Hongbin Sun, Shuchao Ge, Yuan Cai, Yue Yuan, Zijuan Hai, Tongxiang Tao, Jinming Hu,* Bing Hu,* Junfeng Wang,* and Gaolin Liang*. Furin-Controlled Fe3O4 Nanoparticle Aggregation and 19F Signal “Turn-On” for Precise MR Imaging of Tumor. Adv. Funct. Mater. 2019,1903860 (DOI: 10.1002/adfm.201903860).
120, Jiali Tan,* Mei Zhang, Zijuan Hai, Chengfan Wu, Jiong Lin, Wen Kuang, Hang Tang, Yulei Huang, Xiaodan Chen, and Gaolin Liang*. Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano 2019, 13(5), 5616-5226(DOI: 10.1021/acsnano.9b00788).
119, Zijuan Hai, Yanhan Ni, Dilizhatai Saimi, Hongyi Yang, Haiyang Tong, Kai Zhong,* and Gaolin Liang*. γ-Glutamyltranspeptidase-Triggered Intracellular Gadolinium Nanoparticle Formation Enhances the T2-Weighted MR Contrast of Tumor. Nano Lett. 2019, 19(4), 2428-2433(DOI: 10.1021/acs.nanolett.8b05154).
118, Peiyao Chen,# Yinchu Ma,# Zhen Zheng,# Chengfan Wu, Yucai Wang,* and Gaolin Liang*. Facile syntheses of conjugated polymers for photothermal tumour therapy. Nat. Commun. 2019,  10, 1192 (DOI: 10.1038/s41467-019-09226-6).
131, Miaomiao Zhang, Yong Guan, Zheng Dang, Pinggen Zhang, Zhen Zheng, Liang Chen, Wen Kuang, Chenchen Wang, Gaolin Liang*.Directly observing intracellular nanoparticle formation with nanocomputed tomography. Sci. Adv., 2020, 6, eaba3190 (DOI: 10.1126/sciadv.aba3190).
130, Jihua Chen, Yinchu Ma, Wei Du, Tianyue Dai, Yanfang Wang, Wei Jiang, Yifei Wan, Yucai Wang, Gaolin Liang* and Guangfeng Wang*. Furin-Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy. Adv. Funct. Mater., 2020, 2001566 (DOI: 10.1002/adfm.202001566).
129, Meihui Zhuang, Zhuanghao Hou, Peiyao Chen, Gaolin Liang* and Guangming Huang*. Introducing charge tag via click reaction in living cells for single cell mass spectrometry. Chem.Sci., 2020, 11, 7308 (DOI: 10.1039/d0sc00259c).
128, Mengya Lv, Yanhao Zhang, Jiayi Fan, Yanyun Yang, Sheng Chen*, Gaolin Liang*, and Shusheng Zhang*. A near-infrared fluorescent probe for ratiometric sensing of SO2 in cells and zebrafish. Analyst 2020, Advance Article (DOI: 10.1039/d0an01468k).
127, Yaguang Wang, Xiaohu Li, Peiyao Chen, Yu Dong, Gaolin Liang* and Yongqiang Yu*. Enzyme-instructed self-aggregation of Fe3O4 nanoparticles for enhanced MRI T2 imaging and photothermal therapy of tumors. Nanoscale 2020, 12, 1886 (DOI: 10.1039/c9nr09235h).
126, Yanfang Wang, Wei Du, Tong Zhang, Yu Zhu, Yanhan Ni, Chenchen Wang, Fatima Maria Sierra Raya,
Liwei Zou, Longsheng Wang,* and Gaolin Liang*. A Self-Evaluating Photothermal Therapeutic Nanoparticle. ACS Nano 2020, 14, 9585−9593 (DOI: 10.1021/acsnano.9b10144).